Developmental changes in the rat atriopeptin hormonal system.

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Developmental changes in the rat atriopeptin hormonal system.

We undertook a study of fetal synthesis, storage, and release of atriopeptin (AP). Plasma levels of both atriopeptin immunoreactivity (APir) and the NH2-terminal fragment of the prohormone immunoreactivity (NTFir) were very high in the fetus (4 and 20 times the maternal plasma, respectively). However, the atrial content of the AP was low, but surprisingly, ventricular content of AP was quite hi...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1987

ISSN: 0021-9738

DOI: 10.1172/jci112957